Dense electrode array current optimization for targeted and directional tDCS

Dense array transcranial direct current stimulation (tDCS) is an emerging tool to modulate brain function noninvasively via high-density electrode arrays (64-512 electrodes) placed on the subject’s scalp. However, there is need for adequate methods to determine stimulus patterns for such arrays as the degrees of freedom is much higher than conventional two patch electrode configurations. This talk will discuss a method for calculating electrode stimulus patterns for targeted and directional modulation in tDCS. It details the construct and development of an optimization problem that provides an optimal, unique stimulus pattern as a solution that meets a flexible set of safety constraints. The problem is extended to find sub-optimal stimulus patterns that use fewer current sources and thus are more practical in a clinical setting. Exemplary results for both empirical and MR imaging data based brain target regions of interest are shown.

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